Director/Senior Director, Corporate Communications

Who We Are:

Xenon Pharmaceuticals (NASDAQ:XENE https://www.nasdaq.com/market-activity/stocks/xene) is a neuroscience-focused biopharmaceutical company dedicated to drug discovery, clinical development, and commercialization of life-changing therapeutics for patients in need. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team.

What We Do:

We are advancing an exciting product pipeline https://xenon-pharma.com/pipeline to address indications with high unmet medical need, including epilepsy, depression and pain. Our Phase 3 azetukalner program represents the most advanced, clinically validated potassium channel modulator in late-stage clinical development for multiple indications. In March 2026, we announced positive topline data from our Phase 3 X-TOLE2 study of azetukalner in focal onset seizures (FOS), and we submitted a New Drug Application to the Food and Drug Administration in the third quarter of 2026. Our Phase 3 epilepsy program also includes a second FOS study, X-TOLE3, which would support regulatory submissions outside the U.S., and the X-ACKT study in primary generalized tonic-clonic seizures, which would support regulatory submissions for an additional epilepsy indication. We also have multiple Phase 3 azetukalner clinical trials underway in major depressive disorder (MDD) and bipolar depression (BPD), based on topline data from our Phase 2 X-NOVA clinical trial. In addition, we are proud of our strong heritage in human genetics, deep understanding of ion channel biology, and expertise in novel chemistries to enable potent, selective ion channel targeting. We continue to advance an early-stage pipeline of novel therapeutic candidates, including Phase 1 studies for XEN1701 and XEN1720 (targeting Nav1.7) and XEN1120 (targeting Kv7), which are being developed for pain. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations.

We are seeking a Director/Senior Director, Corporate Communications, to join our team. The Director/Senior Director will be responsible for developing and executing communications strategies to promote and protect the Company's reputation, with a specific focus on initiatives that build awareness of Xenon and the company’s emerging commercial product portfolio. This leader will provide strategic execution of tactical implementation associated with corporate newsflow, including business updates, clinical trial milestones, data readouts and future product launches. This role will also work to ensure external and internal communications are closely aligned to ensure teams are upholding our culture and shared values: Xenon CARES about patients, employees and those who put their trust in us.

In partnership with the Senior Vice President of Corporate Affairs and the broader Corporate Affairs team, this role will work with corporate, commercial, medical, and senior leaders to execute the Corporate and Product Communications strategy, and effectively develop messaging and communications around our clinical, regulatory, and commercial progress for various stakeholder groups, including investors and media, healthcare professionals, and the patient community. This role will work closely with the Corporate Communications team, Executive Leadership Team, as well as the Patient Advocacy, Clinical Development, Medical Affairs, Commercial, Legal and Regulatory departments to maintain an in-depth understanding of corporate and brand strategies, commercial performance, and pipeline progress.

This is a high-impact role ideal for a communications professional with corporate and brand communications experience who thrives in a dynamic, fast-paced biotech environment and can bridge science, strategy, and our commitment to patient and HCP communities. The ideal candidate has significant depth of expertise in U.S. brand launches and business strategies and is a critical thinker with strong problem-solving skills. The ideal candidate is also a strong communicator who collaborates effectively with key functions to communicate the corporate and product story. Reporting to the Executive Director of Corporate Communications, this position will be part of the Corporate Affairs team and located in our Greater Boston location, in Needham, MA, USA.

RESPONSIBILITIES:

• Increase awareness and visibility of Xenon’s emerging leadership in epilepsy, including forthcoming potential launch of azetukalner in focal seizures and our emergence as a leading biopharma company soon to be a fully integrated commercial organization.

• Collaborate with Corporate Affairs, the Executive Leadership team, and leaders in Commercial and Medical Affairs to craft clear, consistent messaging and execute communications strategies related to company strategy, the late-stage/future commercial product portfolio, and milestones, including regulatory, commercial and data milestones for azetukalner.

• Contribute to quarterly earnings announcements through late-stage pipeline-specific content development, including in press releases, scripts, Q&As, 10-K/10-Qs, corporate presentations, etc. in collaboration with the CEO, CFO, CCO, CMO and Corporate Affairs.

• Support investor-focused pipeline, financial, and corporate strategy communications, including messaging preparation for banking conferences and other investor events.

• Lead or support development of corporate and investor presentations.

• Help maintain investor website with current information about the pipeline, events and investor materials.

• Lead development of corporate and late-stage product messaging and materials, including press releases, Q&As, executive talking points, social media content, etc., in collaboration with Corporate Affairs, Medical Affairs, Clinical Development, Commercial, Legal, Regulatory, and oth