Senior Director, Development Operations & Biometrics, Strategy & Operational Excellence.

About Us Kardigan is a heart health company working to make cardiovascular disease preventable, curable and no longer the leading cause of death in the world. It is Kardigan’s mission to develop multiple targeted treatments in parallel that bring people with cardiovascular diseases to the cures they deserve.

Led by Tassos Gianakakos, Jay Edelberg, M.D., Ph.D., and Bob McDowell, Ph.D., Kardigan’s co-founders have reunited after leading MyoKardia to discover and develop mavacamten, the first cardiac myosin inhibitor, resulting in an acquisition by Bristol Myers Squibb in 2020.

We have a cutting-edge discovery and translational research platform, a pipeline of late-stage candidates, and an industry-leading team that is driven to improve the lives of patients.

At Kardigan, we are motivated by our values which guide how we work, interact, and achieve our goals. Driven by patients and their families , we are deeply committed to improving the lives of patients and prioritizing their needs above all else. We believe in being authentic —leading with truth to bring out the best in others by creating an environment where every person knows they will be fully accepted. With an eagerness to learn , we encourage the highest levels of curiosity and are open to changing our minds. We are committed to winning as a team with urgency, excellence, and intention, and support each other no matter what role we play or where we sit. Lastly, we strive to enable the impossible because patients are counting on us. We are not afraid to take risks to unlock innovation and advance scientific discoveries.

These values are the foundation of our work, empowering us to make a real difference, every day.

Department: Development Operations & Biometrics (DO&BM) Reports To: Head of Development Operations & Biometrics Location: Princeton, NJ, United States Travel: Approximately 10–20% Job Overview Kardigan is seeking a Senior Director, DO&BM Strategy & Operational Excellence to serve as a trusted advisor to the Head of DO&BM and the strategic integrator for the function, aligning priorities, governance, operating practices, and cross-functional execution to enable high-quality clinical development across the product lifecycle. This is a dual-mandate role. On one side, the Senior Director sets and drives DO&BM’s strategic agenda—organizational design, annual planning, governance, performance management, and leadership-team effectiveness—ensuring DO&BM operates as a coordinated, high-performing organization aligned to corporate objectives. On the other, the Senior Director leads the advancement of Risk-Based Quality Management (RBQM), Quality by Design (QbD), process simplification, and data- and technology-enabled ways of working across the clinical development organization. Reporting directly to the Head of Development Operations & Biometrics, the Senior Director will serve as a trusted strategic partner to senior leaders within DO&BM and partner across Clinical Development, Quality, Regulatory, Pharmacovigilance, Finance, and IT to translate strategy into practical operating models, standards, processes, governance, and solutions that strengthen organizational effectiveness and improve quality, compliance, efficiency, and speed across the clinical development portfolio. The successful candidate will bring deep knowledge of clinical drug development, exceptional organizational and communication skills, and the ability to influence outcomes without direct authority in a fast-paced biotech environment. This role starts with a small team and is mandated to build capability over time. Key Responsibilities DO&BM Strategy & Organizational Leadership

Lead the strategic planning and execution of DO&BM initiatives aligned with corporate objectives. Oversee and optimize organizational design and delivery through process improvement, change management, and performance tracking; lead and manage the Operational Excellence team and partner with cross-functional Strategy & Operations counterparts to ensure enterprise alignment. Identify emerging risks, opportunities, and organizational challenges, providing recommendations and actionable solutions to the DO&BM leadership team. Lead the annual planning process for the function, including budget development, resource allocation, and goal setting. Develop and maintain global standards and best practices for DO&BM in collaboration with key cross-functional partners. Own the metrics and KPI framework that monitors organizational health and performance, including functional scorecards and quarterly business review materials. Standardize onboarding and recruitment practices and lead functional initiatives focused on talent, capability, and career development.

Leadership Team Effectiveness & Governance

Design and run the DO&BM governance model—decision rights, forums, cadence, and escalation paths—so that the leadership team operates with clarity and speed. Set the agenda for and lead key leadership forums, including senior leadership team meetings, town halls, and off-sites, driving content, decision capture, and accountability for follow-through. Shape and author functional and executive communications and presentations that carry the leadership team’s message consistently across the organization. Represent DO&BM leadership at internal and external forums as applicable. Build strong partnerships across Clinical Development, Quality, Regulatory, Technology, G&A, and external partners. Lead cross-functional teams and strategic programs involving multiple functions, vendors, and technology partners. Build, lead, and mentor a small high-performing team, scaling the capability as the portfolio and organization grow.

Operational Excellence

Define and lead enterprise-wide transformation strategies (including change management approaches) that simplify and standardize end-